Nottingham Forest take on Premier League strugglers West Ham from midday.
Elsewhere, Sunderland host Carlisle at the Stadium of Light from 2pm.
Chelsea are away to Championship side Derby County at Pride Park from 2.15pm.
Liverpool host Oldham Athletic from 3pm.
Also at 3pm, Port Vale host Plymouth.
And the big game of the day is at Old Trafford, where Manchester United host Swansea from 4.30pm.